Lithium Hydroxide → 5-(2-Furyl)isoxazole-3-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[O:8][N:7]=1)=[O:5])C.[OH-].[Li+]>C1COCC1.CO>[O:12]1[CH:13]=[CH:14][CH:15]=[C:11]1[C:9]1[O:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=1参加物
5
実験手順
To a solution of 5-furan-2-yl-isoxazole-3-carboxylic acid ethyl ester (4.14 g) in THF (130 mL) and methanol (25 mL) was slowly added 1N lithium hydroxide aqueous solution (80 mL). The resulting mixture was stirred for 15 hours, and then concentrated under reduced pressure. The remaining solution was acidified with 1N hydrochloric acid to form a solid, and the solid was filtered, washed with distilled water, dried to give 3.22 g of 5-furan-2-yl-isoxazole-3-carboxylic acid (yield: 90%) as a white solid.
後処理
- concentrationconcentrated under reduced pressure
- customto form a solid
- filtrationthe solid was filtered
- washwashed with distilled water
- customdried
出典と根拠
- ORDレコード
- ord-5f015aed813540e08b758222af6fb3dd
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518978B2
反応ノート
読み込み中…