Pyridine → N-(2-hydroxy-5-nitrophenyl)butanamide

HRID 1896786

反応式

HRID 1896786 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].N1C=CC=CC=1.[C:18](Cl)(=[O:22])[CH2:19][CH2:20][CH3:21]>ClCCl>[OH:11][C:3]1[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=1[NH:1][C:18](=[O:22])[CH2:19][CH2:20][CH3:21]

参加物

5

反応物 3

HCID 1049PyridineHCID 8855Butyryl chlorideHCID 36133892-Amino-4-Nitrophenol

生成物 1

HCID 3599768N-(2-hydroxy-5-nitrophenyl)butanamide収率 34%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-amino-4-nitrophenol (10 g, 64.9 mmol) in dichloromethane (250 mL) under nitrogen at 0° C. was added pyridine (10.5 mL, 129.9 mmol) followed by butyryl chloride (7.05 mL, 68.2 mmol) over a period of 5 min. After 30 min at 0° C., the solution was left warming up to room temperature for 2 days. The organic layer was washed with aqueous copper sulfate solution and brine. Insoluble material from the aqueous layer was filtered off and washed with water to afford 4.95 g (34%) of the title compound.

後処理

  1. waitthe solution was left
  2. washThe organic layer was washed with aqueous copper sulfate solution and brine
  3. filtrationInsoluble material from the aqueous layer was filtered off
  4. washwashed with water

出典と根拠

ORDレコード
ord-dbfe4d536cbc491a93d8c0c88be0fe2a
出典データセット
uspto-grants-2013_08
特許番号
US08518980B2

関連ノート

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