Thionyl Chloride → 6-Fluoro-2-naphthoyl chloride

HRID 1897577

反応式

HRID 1897577 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.S(Cl)([Cl:17])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:17])=[O:14])[CH:6]=[CH:5]2

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 27827886-Fluoro-2-naphthoic acid

生成物 1

HCID 866748346-Fluoro-2-naphthoyl chloride

実験手順

6-fluoro-2-naphthoic acid (2 g, 10.52 mmol) was stirred in thionyl chloride (21.03 ml) at 80° C. for 4 h in pressure vessel. The mixture was cooled and concentrated. The acid chloride was dried and used as is for next step.

後処理

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated
  3. dry with materialThe acid chloride was dried

出典と根拠

ORDレコード
ord-9bce67345cf24d389ebf4192955b9154
出典データセット
uspto-grants-2013_08
特許番号
US08519134B2

関連ノート

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