Trifluoroacetic acid → HCID 58097152、化合物
反応式
[OH:1][C:2]1([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]3[S:24][CH:25]=[CH:26][N:27]=3)[N:17]=2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[S:24]1[CH:25]=[CH:26][N:27]=[C:23]1[NH:22][C:18]1[N:17]=[C:16]([CH2:15][C:2]2([OH:1])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]2)[CH:21]=[CH:20][CH:19]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of 5.9 mg of tert-butyl 4-hydroxy-4-((6-(1,3-thiazol-2-ylamino)pyridin-2-yl)methyl)piperidine-1-carboxylate in 1 ml of chloroform was added 0.5 ml of trifluoroacetic acid at 0° C., followed by stirring the reaction mixture at 0° C. for 2 hours. The reaction mixture was concentrated in vacuo, basified with saturated aqueous sodium bicarbonate solution, and extracted with chloroform. The resulting chloroform layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated in vacuo to give the title compound as a brown oil.