Methyl iodide → 4-Iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
反応式
[I:1][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[H-].[Na+].I[CH3:14]>CN(C=O)C>[I:1][C:2]1[C:3]2[CH:10]=[CH:9][N:8]([CH3:14])[C:4]=2[N:5]=[CH:6][N:7]=1参加物
5
実験手順
206 mg (0.84 mmol) of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine was dissolved in 1 mL DMF. 37 mg (0.92 mmol) of 60% sodium hydride was added followed by 58 μL (0.92 mmol) of iodomethane. The reaction was quenched by adding 10 mL of water, the solid filtered off, washed with 10 mL of water, then 10 mL of hexanes and dried. Yield: 142 mg of a tan powder, 90% pure.
後処理
- customThe reaction was quenched
- additionby adding 10 mL of water
- filtrationthe solid filtered off
- washwashed with 10 mL of water
- dry with material10 mL of hexanes and dried
出典と根拠
- ORDレコード
- ord-ac5ed1f2fd5a468ab19502ad4102a971
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08519135B2
反応ノート
読み込み中…