Thiophosgene → 2-Chloro-4-methylphenyl isothiocyanate

反応式

[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(C(C)C)C(C)C)C>>[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]

参加物

反応物 3

HCID 10040Thiophosgene

HCID 120072-Chloro-p-toluidine

HCID 81531Diisopropylethylamine

生成物 1

HCID 1435292-Chloro-4-methylphenyl isothiocyanate収率 58.3%

実験手順

The title compound was prepared following the procedure described for intermediate-2 using 2-chloro-4-methyl aniline (2.0 g, 14.00 mmol), thiophosgene (1.62 g, 14.00 mmol) and N-ethyl di-isopropyl amine (3.63 g, 28.00 mmol) to afford 1.5 g of the desired product.