Methyl iodide → 2-Chloro-1-methoxy-3-methyl-4-nitrobenzene

HRID 1898991ノート

反応式

HRID 1898991 の反応式
[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[OH:12].[H-].[Na+].[CH3:15]I>CN(C=O)C>[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[O:12][CH3:15]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 131473552-Chloro-3-methyl-4-nitrophenol

生成物 1

HCID 137023832-Chloro-1-methoxy-3-methyl-4-nitrobenzene収率 81.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-Chloro-3-methyl-4-nitrophenol (9.39 g, 50.0 mmol) was reacted with sodium hydride (50%, 2.64 g, 55.0 mmol) and methyl iodide (7.81 g, 55.0 mmol) in dry DMF (200 ml) by the method described in 1 (a). After treatment with water, the product was extracted with chloroform, and the dried extract evaporated to dryness, leaving an oil which crystallised on cooling, leaving solid 2-chloro-3-methyl-4-nitroanisole (8.19 g).

後処理

  1. extractionAfter treatment with water, the product was extracted with chloroform
  2. extractionthe dried extract
  3. customevaporated to dryness
  4. customleaving an oil which
  5. customcrystallised
  6. temperatureon cooling

出典と根拠

ORDレコード
ord-7a595a9bb28245488bfb0cabff633f57
出典データセット
uspto-grants-1996_11
特許番号
US05571833

反応ノート

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