2,4-Difluoroaniline → 2-bromo-N-(2,4-difluorophenyl)acetamide

HRID 1899393ノート

反応式

HRID 1899393 の反応式
[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[Br:10][CH2:11][C:12](Cl)=[O:13].CCN(C(C)C)C(C)C>ClCCl>[Br:10][CH2:11][C:12]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=1[F:1])=[O:13]

参加物

5

反応物 3

HCID 97092,4-DifluoroanilineHCID 81531DiisopropylethylamineHCID 89602Bromoacetyl chloride

生成物 1

HCID 34164012-bromo-N-(2,4-difluorophenyl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5.16 g (40 mmol) of 2,4-difluoroaniline and 6.3 g (40 mmol) of bromoacetyl chloride are treated in 200 ml of dichloromethane with 5.17 g (40 mmol) of Hunig base. After 4 h, the mixture is washed twice with 1N hydrochloric acid and once with water, dried (MgSO4) and concentrated.

後処理

  1. washthe mixture is washed twice with 1N hydrochloric acid and once with water
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-d4b3cbeaf5614edda9a0e9989ab48ab0
出典データセット
uspto-grants-1996_11
特許番号
US05571921

反応ノート

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