Hydrochloric Acid → 2-Aminomethyl-5,8-dimethyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one.HCl

HRID 1900812ノート

反応式

HRID 1900812 の反応式
[N:1]([CH2:4][CH:5]1[O:20][C:8]2=[C:9]3[C:14](=[C:15]([CH3:17])[CH:16]=[C:7]2[CH2:6]1)[NH:13][C:12](=[O:18])[C:11]([CH3:19])=[CH:10]3)=[N+]=[N-].[H][H].[ClH:23]>O1CCCC1.[Pd]>[NH2:1][CH2:4][CH:5]1[O:20][C:8]2=[C:9]3[C:14](=[C:15]([CH3:17])[CH:16]=[C:7]2[CH2:6]1)[NH:13][C:12](=[O:18])[C:11]([CH3:19])=[CH:10]3.[ClH:23]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 233697942-Azidomethyl-5,8-dimethyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 678029552-Aminomethyl-5,8-dimethyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one.HCl収率 73.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-Azidomethyl-5,8-dimethyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one (2.76 g, 10.2 mmol) was dissolved in tetrahydrofuran (200 ml), to which 10% palladium-on-carbon (2.76 g) was added. The mixture was stirred at room temperature for 2 hours in the atmospher of hydrogen. The catalyst was filtered off, and the filtrate was condensed. The residue was converted to a hydrochloric acid salt, and then subjected to recrystallization (methanol-ether) to obtain 2.10 g of the title compound as yellow crystals (73.4%).

後処理

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. customcondensed
  4. customsubjected to recrystallization (methanol-ether)

出典と根拠

ORDレコード
ord-7c3250196be54bc4a9025e41bb5d35e5
出典データセット
uspto-grants-1996_11
特許番号
US05576324

反応ノート

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