8-Methyl-7-nitroquinoline → HCID 14115670、化合物

HRID 1901241ノート

反応式

HRID 1901241 の反応式
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:12][C:3]1[C:2]([CH3:1])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 2541658-Methyl-7-nitroquinolineHCID 2723923Ammonium formate

生成物 1

HCID 14115670HCID 14115670、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 8-methyl-7-nitroquinoline (1.8 g) in methanol (20 mL)is added Pd/C (10%, 0.45 g) and ammonium formate (2.77 g). The mixture is stirred at room temperature for 30 minutes, then filtered on Celite, with methanol wash of the solids. The filtrate is rotary evaporated and the residue partitioned between H2O and CH2Cl2. The organic layer is dried over potassium carbonate, filtered and rotary evaporated to afford 7-amino-8-methylquinoline as a yellow solid.

後処理

  1. filtrationfiltered on Celite, with methanol
  2. washwash of the solids
  3. customThe filtrate is rotary evaporated
  4. customthe residue partitioned between H2O and CH2Cl2
  5. dry with materialThe organic layer is dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

出典と根拠

ORDレコード
ord-919c70c680954da5b67fc9d1a2bd54de
出典データセット
uspto-grants-1996_11
特許番号
US05576437

反応ノート

読み込み中…