5-Bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran → 5-Bromo-2-[2-(4-methoxyphenyl)ethyl]benzofuran

HRID 1901334ノート

反応式

HRID 1901334 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]=[CH:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)=[CH:7][C:6]=2[CH:20]=1>O1CCCC1.C(O)C.[Pt](=O)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)=[CH:7][C:6]=2[CH:20]=1

参加物

5

反応物 1

HCID 537809305-Bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran

生成物 1

HCID 218443105-Bromo-2-[2-(4-methoxyphenyl)ethyl]benzofuran収率 75.4%

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

128 g of 5-bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran as a mixture of two stereoisomers was dissolved in a solvent mixture of 1.3 l of tetrahydrofuran and 0.7 l of ethanol. The resulting solution was mixed with 3.0 g of platinum dioxide and subjected to 4 hours of catalytic hydrogenation under normal pressure. Thereafter, the catalyst was removed by filtration, the resulting filtrate was concentrated, and crystals thus precipitated were collected by filtration and washed with ethanol. In this way, 97.08 g of 5-bromo-2-[2-(4-methoxyphenyl)ethyl]benzofuran was obtained.

後処理

  1. customThereafter, the catalyst was removed by filtration
  2. concentrationthe resulting filtrate was concentrated
  3. customcrystals thus precipitated
  4. filtrationwere collected by filtration
  5. washwashed with ethanol

出典と根拠

ORDレコード
ord-41132653fb354830b2444dc1a62b6cae
出典データセット
uspto-grants-1996_11
特許番号
US05576343

反応ノート

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