L-Methionine → N-[(2-Aminophenyl)methyl]-L-methionine

HRID 1902394ノート

反応式

HRID 1902394 の反応式
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[NH2:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH2:13][S:14][CH3:15].C(=O)([O-])[O-].[Na+].[Na+].[BH4-].[Na+]>O>[NH2:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[CH2:1][NH:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH2:13][S:14][CH3:15]

参加物

6

反応物 4

HCID 6137L-MethionineHCID 10340Sodium CarbonateHCID 682552-AminobenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 13340364N-[(2-Aminophenyl)methyl]-L-methionine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 0.1 mol of anthranil aldehyde, 0.1 mol of methionine and a solution of 0.1 mol of sodium carbonate in 50 ml of water was stirred for a few hours. After everything had gone into solution, 0.1 mol of sodium borohydride was added, and the mixture was stirred at room temperature for 12 hours. The reaction solution was then acidified to pH3, and the precipitate was collected and dried, yielding 85% of theory of N-(2-amino-benzyl)-methionine, m.p. 198° C. The total yield, based on the anthranilic acid starting material, was 68% of theory.

後処理

  1. additionwas added
  2. customthe precipitate was collected
  3. customdried

出典と根拠

ORDレコード
ord-a394203afa7c4ba28ada684d91a0a6c7
出典データセット
uspto-grants-1982_12
特許番号
US04363766

反応ノート

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