Dimethyl Sulfate → 1,3-Dichloro-4-methoxy-2-nitrobenzene
反応式
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[CH:5]=[CH:4][C:3]=1[OH:12].[OH-].[Na+].S(OC)(O[CH3:19])(=O)=O>C(Cl)Cl.[Cl-].C([N+](C)(C)C)C1C=CC=CC=1.O>[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[CH:5]=[CH:4][C:3]=1[O:12][CH3:19]参加物
7
実験手順
A solution of 155.4 g of 2,4-dichloro-3-nitrophenol in 2 l of methylene chloride is treated with 16.9 g of benzyltrimethylammonium chloride. There is added thereto a solution of 44.8 g of sodium hydroxide in 1.8 l of water and, while stirring vigorously, 143 ml of dimethyl sulfate. After 1 hour, the organic phase is separated, washed with water, dried and evaporated in vacuo. There is obtained 2,4-dichloro-3-nitroanisole of melting point 97°-99° (hexane).
後処理
- additionThere is added
- customthe organic phase is separated
- washwashed with water
- customdried
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-b4b0d6bc19a14b90a43aaa7fe88e31f1
- 出典データセット
- uspto-grants-1982_12
- 特許番号
- US04366160
反応ノート
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