Thionyl Chloride → 2-(1-Chloroethyl)-1,3-difluorobenzene

HRID 1903831ノート

反応式

HRID 1903831 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[CH:4](O)[CH3:5].S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[CH:4]([Cl:14])[CH3:5]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 50120752,6-Difluoro-alpha-methylbenzyl alcohol2 回

生成物 1

HCID 5880552-(1-Chloroethyl)-1,3-difluorobenzene収率 99.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
60 °C

実験手順

2,6-Difluoro-alpha-methylbenzyl alcohol of (B) (14.9 g, 0.094 mol) is dissolved in chloroform (50 ml) and warmed to 60° C. Thionyl chloride (22.4 g, 0.19 mol) is now added dropwise. The whole is kept at 60° C. for 4 hours then stirred overnight at room temperature. Excess thionyl chloride and chloroform are then removed on a rotary evaporator, resulting in pure title product (16.6 g, 99.8%).

後処理

  1. customExcess thionyl chloride and chloroform are then removed on a rotary evaporator

出典と根拠

ORDレコード
ord-05eb1a4e6dd5472fb76ab7ef7c7bbbc6
出典データセット
uspto-grants-1984_03
特許番号
US04438271

反応ノート

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