Tetrahydrofuran → 4-(4-Dimethylaminomethyl-2-pyridyl)butylamine

HRID 1904079

反応式

HRID 1904079 の反応式
[C:1]([CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[C:10]([CH2:12][N:13]([CH3:15])[CH3:14])[CH:9]=[CH:8][N:7]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.[OH-].[Na+]>C(OCC)C.O>[CH3:14][N:13]([CH2:12][C:10]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:5][CH2:4][CH2:3][CH2:1][NH2:2])[CH:11]=1)[CH3:15]

参加物

7

反応物 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 132926072-(3-Cyanopropyl)-4-dimethylaminomethylpyridineHCID 21226445Aluminium lithium hydride

生成物 1

HCID 202390724-(4-Dimethylaminomethyl-2-pyridyl)butylamine収率 100%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒2 回

実験手順

2-(3-Cyanopropyl)-4-dimethylaminomethylpyridine (1 g) in diethyl ether (15 ml) was added dropwise to a rapidly stirred suspension of lithium aluminium hydride (0.76 g) in ether (45 ml). The solution was stirred for 2.5 hours. Wet tetrahydrofuran, followed by 16% sodium hydroxide (1 ml) and then water was added and the mixture was filtered. The filtrate was evaporated to give 4-(4-dimethylaminomethyl-2-pyridyl)butylamine (1.02 g) as a clear oil.

後処理

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-4d71750b95ff4131a5700a84b98f2eb3
出典データセット
uspto-grants-1984_03
特許番号
US04439609

関連ノート

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