4-Hydroxybenzaldehyde → p-Octyloxycarbonyloxybenzaldehyde

HRID 1905599

反応式

HRID 1905599 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.Cl[C:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:12].C1(C)C=CC=CC=1.Cl>N1C=CC=CC=1>[CH2:14]([O:13][C:11]([O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)=[O:12])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

参加物

6

反応物 4

HCID 1264-HydroxybenzaldehydeHCID 313Hydrochloric AcidHCID 1140TolueneHCID 81956Carbonochloridic acid, octyl ester

生成物 1

HCID 13828007p-Octyloxycarbonyloxybenzaldehyde収率 65.8%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Commercially available p-hydroxybenzaldehyde (50 g) was dissolved in pyridine (400 ml), followed by dropwise adding octyl chloroformate (85 g) under ice cooling, heating on a water bath, allowing to stand overnight, adding toluene (300 ml), further adding 6N-hydrochloric acid, separating the liquid layer, further washing with 2N-NaOH aqueous solution, washing with water, drying, and distilling off toluene to obtain a raw product of p-octyloxycarbonyloxybenzaldehyde (75 g).

後処理

  1. temperatureheating on a water bath
  2. customseparating the liquid layer
  3. washfurther washing with 2N-NaOH aqueous solution
  4. washwashing with water
  5. customdrying
  6. distillationdistilling off toluene

出典と根拠

ORDレコード
ord-9680c9fed5314658aeb7f9a78be33508
出典データセット
uspto-grants-1987_03
特許番号
US04647398

関連ノート

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