Methane → Dl-Phenylalanine

HRID 1905819

反応式

HRID 1905819 の反応式
[CH2:1]([CH:8]1[NH:12]C(=O)N[C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:15].[Na+].C.Cl>>[NH2:12][CH:8]([C:9]([OH:14])=[O:15])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 735655-(Phenylmethyl)-2,4-imidazolidinedione

生成物 1

HCID 994Dl-Phenylalanine収率 72%

実験手順

95.1 g (0.5 mole) of 5-benzyl-hydantoin are heated to boiling in 350 ml of a 20% sodium hydroxide solution for 30 hours. The reaction mixture is clarified with activated charcoal and acidified with concentrated hydrochloric acid (pH 2). The precipitate (hydrantoinic acid) is filtered off and the phenyl alanine is precipitated from the filtrate as described in Example 11. Thus 59.5 g of the dry desired compound are obtained, yield 72%. Purity: 97.5% (according to HPLC).

後処理

  1. filtrationThe precipitate (hydrantoinic acid) is filtered off
  2. customthe phenyl alanine is precipitated from the filtrate
  3. dry with materialThus 59.5 g of the dry desired compound
  4. customare obtained

出典と根拠

ORDレコード
ord-6e1f3bdc80a248e58d49025324ccd378
出典データセット
uspto-grants-1987_03
特許番号
US04647694

関連ノート

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