Nitric Acid → HCID 20213361、化合物

HRID 1905870ノート

反応式

HRID 1905870 の反応式
[CH3:1][N:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:6][C:5](=[O:16])[N:4]([CH3:17])[C:3]1=[O:18].S(=O)(=O)(O)O.[N+:24]([O-])([OH:26])=[O:25].[OH-].[Na+]>C(O)(=O)C>[CH3:1][N:2]1[C:7]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH3:15])=[C:12]([N+:24]([O-:26])=[O:25])[CH:13]=2)=[CH:6][C:5](=[O:16])[N:4]([CH3:17])[C:3]1=[O:18]

参加物

6

反応物 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 140964746-(4-Methoxyphenyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 20213361HCID 20213361、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 1,3-dimethyl-6-(4-methoxyphenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (4.4 g) in acetic acid (22 ml) were added conc.sulfuric acid (9 ml) and conc. nitric acid (18 ml) under ice-cooling. The mixture was stirred at 5°-10° C. for 1.5 hours and at ambient temperature further for 2 hours. The mixture was poured into ice-water, and stirred. After the aqueous mixture was neutralized with aqueous sodium hydroxide, the resultant precipitates were filtered. The precipitates were washed with water and dried in air to give 1,3-dimethyl-6-(4-methoxy-3-nitrophenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (3.67 g).

後処理

  1. stirringstirred
  2. customthe resultant precipitates
  3. filtrationwere filtered
  4. washThe precipitates were washed with water
  5. customdried in air

出典と根拠

ORDレコード
ord-80f73223082543f8a4ec6cc6d2b5a3e7
出典データセット
uspto-grants-1987_03
特許番号
US04649142

反応ノート

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