Cysteamine Hydrochloride → 2-((Thiophen-2-ylmethyl)thio)ethan-1-amine
反応式
Cl.[NH2:2][CH2:3][CH2:4][SH:5].O[CH2:7][C:8]1[S:9][CH:10]=[CH:11][CH:12]=1.[OH-].[Na+]>Cl>[S:9]1[CH:10]=[CH:11][CH:12]=[C:8]1[CH2:7][S:5][CH2:4][CH2:3][NH2:2]参加物
5
実験手順
(b)(i) Cysteamine hydrochloride (9.95 g) was dissolved in concentrated hydrochloric acid (50 ml) and the solution was cooled to 0°. 2-Hydroxymethylthiophene (10 g) was added dropwise to the stirred solution which was maintained at below 5°. The mixture was stirred overnight at room temperature, adjusted to pH 10 with concentrated aqueous sodium hydroxide and extracted with ethyl acetate. The extracts were evaporated and the residue was distilled at 158°-164°/760 mm Hg to give 2-(2-thienylmethylthio)-ethylamine which was converted into the hydrochloride, m.p. 108°-111°, by treatment with ethanolic HCl and ether.
後処理
- temperaturethe solution was cooled to 0°
- temperaturewas maintained at below 5°
- extractionextracted with ethyl acetate
- customThe extracts were evaporated
- distillationthe residue was distilled at 158°-164°/760 mm Hg
出典と根拠
- ORDレコード
- ord-cb78db5a3f4241e496cdeee6443ff19d
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04649141
反応ノート
読み込み中…