Potassium Hydroxide → Bamaluzole

HRID 1906743

反応式

HRID 1906743 の反応式
Cl[C:2]1[C:7]2[N:8]=[CH:9][N:10]([CH3:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][OH:16].[OH-].[K+]>C(#N)C>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][O:16][C:2]1[C:7]2[N:8]=[CH:9][N:10]([CH3:11])[C:6]=2[CH:5]=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 288102-Chlorobenzyl alcoholHCID 9487924-chloro-1-methyl-1H-imidazo(4,5-c)pyridine

生成物 1

HCID 3086242Bamaluzole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 7.5 g of 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine, 7.1 g of 2-chlorobenzyl alcohol, 3.3 g of KOH and 100 ml of acetonitrile is refluxed for 7 hours. The solvent is removed and the residue is worked up in the customary manner (water/methylene chloride) to give 4-o-Chlorobenzyloxy-1-methyl-1H-imidazo(4,5-c)pyridine, m.p. 132°-135°.

後処理

  1. temperatureis refluxed for 7 hours
  2. customThe solvent is removed

出典と根拠

ORDレコード
ord-9c75251ce62041259494c3e9c8a4fb0a
出典データセット
uspto-grants-1987_03
特許番号
US04654350

関連ノート

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