Hydrochloric Acid → HCID 13453787、化合物

HRID 1906832ノート

反応式

HRID 1906832 の反応式
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][S:11][C:12]1[N:13]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:14]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:16]=1.[H-].[Na+].CO.Cl>O1CCCC1.O>[C:29]1([N:13]2[C:14]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:15]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:16]=[C:12]2[S:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:35])=[O:2])[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 24758Sodium hydrideHCID 54312872Methyl 8-[(1,4,5-triphenyl-1H-imidazol-2-yl)sulfanyl]octanoate

生成物 1

HCID 13453787HCID 13453787、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

170 g of 8-(1.4.5-triphenylimidazol-2-yl mercapto)-octanoic acid methyl ester are dissolved in 1.2 l of tetrahydrofurane. 42 g of sodium hydride dissolved in 700 cc. of methanol are added thereto. The mixture is stirred 24 hours at 40° to 50° C., cooled, diluted with about 2 l of water and acidified with delute hydrochloric acid. The crude acid is filtered off, dried and recrystallized from toluene.

後処理

  1. temperaturecooled
  2. filtrationThe crude acid is filtered off
  3. customdried
  4. customrecrystallized from toluene

出典と根拠

ORDレコード
ord-4cefeb0dc46b4426a1a9f5f5700ea78a
出典データセット
uspto-grants-1987_03
特許番号
US04654358

反応ノート

読み込み中…