Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 1907928

反応式

HRID 1907928 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=O)=[CH:4][C:3]=1[F:16].C1([SiH2]C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Rh]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[CH:4][C:3]=1[F:16]

参加物

5

反応物 2

HCID 69888DiphenylsilaneHCID 48474115(4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone

生成物 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

試薬・触媒・溶媒 2

HCID 53249357Carbonyltris(triphenylphosphine)rhodium(I)hydride触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.

出典と根拠

ORDレコード
ord-7f048c54528c4de8b280552f6360c4a3
出典データセット
uspto-grants-2013_12
特許番号
US08598169B2

関連ノート

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