Ammonium formate → 2-Amino-1-[4-(methylthio)phenyl]ethanol
反応式
[N:1]([CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=1)[OH:6])=[N+]=[N-].C([O-])=O.[NH4+]>[Pd].CO>[NH2:1][CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=1)[OH:6]参加物
5
反応条件
- 温度
- 64 °C
実験手順
To a stirred rt suspension consisting of 2-azido-1-(4-methylsulfanyl-phenyl)-ethanol (104.6 mg, 0.50 mmol), 10% Pd/C (100 mg, 0.10 mmol) and MeOH (25 mL) was added ammonium formate (316 mg, 5.0 mmol) under a N2 atmosphere. The resulting mixture was heated at 64° C. for 2 h. After cooling to rt, the catalyst was removed by filtration through a pad of celite and the celite pad washed with MeOH. The filtrate was concentrated and purified (FCC) to yield the title compound (66 mg, 72%).
後処理
- customTo a stirred rt
- temperatureAfter cooling to rt
- customthe catalyst was removed by filtration through a pad of celite
- washthe celite pad washed with MeOH
- concentrationThe filtrate was concentrated
- custompurified (FCC)
出典と根拠
- ORDレコード
- ord-163a3eecfe3a49e2af091b8bf9e71ece
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598202B2
反応ノート
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