Tetrahydrofuran → HCID 67027148、化合物

HRID 1908850ノート

反応式

HRID 1908850 の反応式
[CH2:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([CH3:14])[N:13]=1)[C:8](O)=[O:9])[CH:2]([CH3:4])[CH3:3].CCN(C(C)C)C(C)C.CN(C(O[N:32]1[N:40]=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.NN.C1COCC1>CN(C=O)C.CCOCC>[CH2:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([CH3:14])[N:13]=1)[C:8]([NH:32][NH2:40])=[O:9])[CH:2]([CH3:4])[CH3:3]

参加物

8

反応物 5

HCID 8028TetrahydrofuranHCID 9321HydrazineHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 574372032-Methyl-6-(2-methyl-propyl)-isonicotinic acid

生成物 1

HCID 67027148HCID 67027148、化合物収率 49.7%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2-isobutyl-6-methyl-isonicotinic acid (83 mg, 0.359 mmol) and DIPEA (186 mg, 1.44 mmol) in DMF (6 mL) is added TBTU (127 mg, 0.395 mmol) at rt. The mixture is stirred for 45 min before 1 M hydrazine in THF (1.44 mL, 1.44 mmol) is added and stirring is continued for 2 h. The mixture is diluted with ether (200 mL) and washed with 1M aq. HCl (3×5 mL), 1M aq. NaOH (3×5 mL) and brine (5 mL). The org. phase is separated, dried over MgSO4, filtered and evaporated. The crude product is purified on prep. TLC plates with DCM containing 4% of methanol to give 2-isobutyl-6-methyl-isonicotinic acid hydrazide (37 mg) as a yellow oil; LC-MS: tR=0.44 min, [M+1]+=208.10.

後処理

  1. additionis added
  2. washwashed with 1M aq. HCl (3×5 mL), 1M aq. NaOH (3×5 mL) and brine (5 mL)
  3. customphase is separated
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated
  7. customThe crude product is purified on prep

出典と根拠

ORDレコード
ord-e91ac569da2543b3bd04be4301bec42e
出典データセット
uspto-grants-2013_12
特許番号
US08598208B2

反応ノート

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