反応式
[Cl:1][C:2]1[N:7]=[CH:6][NH:5][C:4]2=[N:8][CH:9]=[CH:10][C:3]=12.C1C(=O)N([Br:18])C(=O)C1>C(Cl)(Cl)Cl>[Br:18][C:10]1[C:3]2[C:4]([NH:5][CH:6]=[N:7][C:2]=2[Cl:1])=[N:8][CH:9]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (5 g, 32.6 mmol) in Chloroform (100 mL) was added NBS (6.08 g, 34.2 mmol), and the reaction mixture was stirred a 70° C. for 3 hours. The reaction was allowed to cool to room temperature, and the mixture was filtered, washing the solid with additional CHCl3 to afford 5-bromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine as an off-white solid.
後処理
- temperatureto cool to room temperature
- filtrationthe mixture was filtered
- washwashing the solid with additional CHCl3
出典と根拠
- ORDレコード
- ord-de520ba181b3408fbfd83e65f1c54dbb
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598156B2
関連ノート
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