Methanol → tert-Butyl 3-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl]-6-hydroxyhexanoate

HRID 1912078ノート

反応式

HRID 1912078 の反応式
C([O:8][CH2:9][CH2:10][CH2:11][CH:12]([C:21]1[C:25]([CH:26]2[CH2:28][CH2:27]2)=[C:24]([CH:29]2[CH2:32][CH:31]([CH2:33][C:34]([CH3:37])([CH3:36])[CH3:35])[CH2:30]2)[O:23][N:22]=1)[CH2:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])C1C=CC=CC=1.CO>[Pd].O1CCCC1>[CH:26]1([C:25]2[C:21]([CH:12]([CH2:11][CH2:10][CH2:9][OH:8])[CH2:13][C:14]([O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:15])=[N:22][O:23][C:24]=2[CH:29]2[CH2:30][CH:31]([CH2:33][C:34]([CH3:37])([CH3:36])[CH3:35])[CH2:32]2)[CH2:27][CH2:28]1

参加物

5

反応物 2

HCID 887MethanolHCID 71127331tert-Butyl 6-benzyloxy-3-[4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl]hexanoate

生成物 1

HCID 71127332tert-Butyl 3-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl]-6-hydroxyhexanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

tert-Butyl 6-benzyloxy-3-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl]hexanoate (980 mg), methanol (10 mL) and tetrahydrofuran (3 mL) were mixed. To the mixture was added 7.5 w/w % palladium on activated carbon (200 mg). The mixture was stirred at RT under hydrogen atmosphere (1 atm) for 5 hr. The catalyst was freshened up, and the mixture was stirred at RT under hydrogen atmosphere (1 atm) overnight. The 7.5 w/w % palladium on activated carbon was filtered off and the filtrate was concentrated in vacuo.

後処理

  1. stirringthe mixture was stirred at RT under hydrogen atmosphere (1 atm) overnight
  2. filtrationThe 7.5 w/w % palladium on activated carbon was filtered off
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-2fa4d51256e84ab791e9e52f57e2995f
出典データセット
uspto-grants-2013_12
特許番号
US08604069B2

反応ノート

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