Sodium Hydroxide → HCID 67112454、化合物

HRID 1914808ノート

反応式

HRID 1914808 の反応式
[NH2:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.[OH-].[Na+].[C:12](Cl)(=[O:15])[CH2:13][CH3:14]>C1COCC1>[C:12]([NH:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1)(=[O:15])[CH2:13][CH3:14]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 62324Propionyl chlorideHCID 1502035Cyclopentanecarboxylic acid, 3-amino-, (1R,3S)-rel- (9CI)

生成物 1

HCID 67112454HCID 67112454、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

100.0 mg (0.77 mmol) (1R,3S)-3-Aminocyclopentane carboxylic acid is stirred in 2.0 mL THF and 0.77 mL (1.55 mmol) sodium hydroxide solution (2 mol/l). 74.0 μL (0.85 mmol) Propionyl chloride is added drop wise and the mixture is stirred at RT over night. The solvent is evaporated. The mixture is stirred at RT over night. The product is purified by RP-HPLC (water+5-95% acetonitrile (with addition of 0.1% TFA)) and lyophilized.

後処理

  1. customThe solvent is evaporated
  2. stirringThe mixture is stirred at RT over night
  3. customThe product is purified by RP-HPLC (water+5-95% acetonitrile (with addition of 0.1% TFA))

出典と根拠

ORDレコード
ord-2cd22e7d56e74f918aad4ab623987221
出典データセット
uspto-grants-2013_12
特許番号
US08614238B2

反応ノート

読み込み中…