Methanol → Benzoic acid, 2-hydroxy-5-iodo-3-methyl-, methyl ester

HRID 1916565

反応式

HRID 1916565 の反応式
[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([I:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(Cl)(Cl)=O.[CH3:17]O>>[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([I:12])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl Chloride2 回HCID 159086852-Hydroxy-5-iodo-3-methylbenzoic acid

生成物 1

HCID 14172484Benzoic acid, 2-hydroxy-5-iodo-3-methyl-, methyl ester

実験手順

A solution of 2.0 g (7.19 mmol) 2-hydroxy-5-iodo-3-methyl-benzoic acid in 5.0 mL thionyl chloride (69.0 mmol) is stirred for 20 min at 80° C. Thionyl chloride is eliminated i.vac. and the residue is combined with 20 mL MeOH and stirred for 20 min at RT. The product is precipitated out of the reaction. MeOH is eliminated i.vac. down to 5 mL and the residue is suction filtered. The product is further reacted without any more purification.

後処理

  1. customThe product is precipitated out of the reaction
  2. filtrationfiltered
  3. customThe product is further reacted without any more purification

出典と根拠

ORDレコード
ord-14bc186e27e24c299a0c3914c5a30543
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

関連ノート

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