Potassium Carbonate → 6-Bromo-2-pyrrolidin-1-ylmethyl-quinoline

HRID 1916628

反応式

HRID 1916628 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12]Br)[CH:6]=[CH:5]2.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH:6]=[CH:5]2

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 589705326-Bromo-2-(bromomethyl)quinoline

生成物 1

HCID 673647966-Bromo-2-pyrrolidin-1-ylmethyl-quinoline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

4.60 g (15.28 mmol) 6-bromo-2-bromomethyl-quinoline are added to a solution of 1.40 mL (16.8 mmol) pyrrolidine and 6.34 g (45.9 mmol) K2CO3 in 50 mL acetonitrile. The reaction is stirred overnight at RT and then the inorganic salts are filtered off. The organic phase is washed with water and the aqueous phase is extracted with EtOAc. The combined organic extracts are dried over MgSO4 and the solvent is eliminated i.vac.

後処理

  1. filtrationthe inorganic salts are filtered off
  2. washThe organic phase is washed with water
  3. extractionthe aqueous phase is extracted with EtOAc
  4. dry with materialThe combined organic extracts are dried over MgSO4

出典と根拠

ORDレコード
ord-e81953fcf971414f8406f0421b472477
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

関連ノート

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