Acetic Acid → HCID 58505643、化合物

HRID 1917603ノート

反応式

HRID 1917603 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[C:15]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[N:22]=4)[CH:16]=[CH:17]3)=[C:12]([C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[C:11]=2[CH2:35][C:36]([CH3:43])([CH3:42])[C:37]([O:39]CC)=[O:38])=[O:9])=[CH:4][CH:3]=1.CC(O)=O>C1COCC1.[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[C:15]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[N:22]=4)[CH:16]=[CH:17]3)=[C:12]([C:29](=[O:34])[C:30]([CH3:32])([CH3:33])[CH3:31])[C:11]=2[CH2:35][C:36]([CH3:43])([CH3:42])[C:37]([OH:39])=[O:38])=[O:9])=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 176Acetic AcidHCID 58505712HCID 58505712、化合物

生成物 1

HCID 58505643HCID 58505643、化合物収率 99.8%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of ethyl 3-{3-[(4-chlorophenyl)carbonyl]-1-(2,2-dimethylpropanoyl)-7-[(6-methoxypyridin-2-yl)methoxy]indolizin-2-yl}-2,2-dimethylpropanoate (20 mg, 0.033 mmol) in THF (2.0 mL) and 10M aqueous NaOH (1.5 mL) is heated at 45° C. for 1.5 h. The mixture is then acidified with HOAc, concentrated in vacuo, and partitioned between EtOAc and water. The organics are collected, dried with MgSO4, filtered, and concentrated in vacuo to give the title compound (19 mg, quant).

後処理

  1. concentrationconcentrated in vacuo
  2. custompartitioned between EtOAc and water
  3. customThe organics are collected
  4. dry with materialdried with MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-19cf73d45fd94019a2344bf8dca9d781
出典データセット
uspto-grants-2013_12
特許番号
US08618300B2

反応ノート

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