Phenyl chloroformate → 5-[2-(3-Chloro-phenyl)-ethoxy]-4-ethyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-phenyl ester

HRID 1918352

反応式

HRID 1918352 の反応式
[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[C:9]([O:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)[CH:8]=[N:7][CH:6]=1)[CH3:2].Cl[C:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:24].[CH2:32]([Mg]Br)[CH3:33]>C1COCC1>[C:26]1([O:25][C:23]([N:7]2[CH:8]=[C:9]([O:11][CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=3)[CH:10]([CH2:32][CH3:33])[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:21])=[CH:6]2)=[O:24])[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

5

反応物 3

HCID 15891Phenyl chloroformateHCID 671698645-[2-(3-Chloro-phenyl)-ethoxy]-nicotinic Acid Ethyl EsterHCID 178418443HCID 178418443、化合物

生成物 1

HCID 671712595-[2-(3-Chloro-phenyl)-ethoxy]-4-ethyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-phenyl ester

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-30 °C

実験手順

The compound of step 1 (100 mg, 0.327 mmol) was dissolved in THF (1.5 ml) and the mixture was cooled to −30° C. Phenyl chloroformate (77.6 mg, 0.49 mmol) was added and the mixture was stirred for 10 minutes. Ethyl magnesiumbromide (0.589 ml, 1M in THF) was added at −30° C. and the mixture was stirred for 30 minutes, partitioned between diethylether and aqueous ammonium chloride solution, the combined organic extracts were dried over sodium chloride and evaporated to dryness in vacuo. The raw material was purified by silica gel chromatography with a heptane/ethyl acetate gradient to yield the title compound (84 mg).

後処理

  1. stirringthe mixture was stirred for 30 minutes
  2. custompartitioned between diethylether and aqueous ammonium chloride solution
  3. dry with materialthe combined organic extracts were dried over sodium chloride
  4. customevaporated to dryness in vacuo
  5. customThe raw material was purified by silica gel chromatography with a heptane/ethyl acetate gradient

出典と根拠

ORDレコード
ord-25408ee88b57454f8d3d98a4f9bc8f07
出典データセット
uspto-grants-2013_12
特許番号
US08618304B2

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