N-(4-methyl-3-nitrophenyl)cyclopropanecarboxamide → N-(3-amino-4-methylphenyl)cyclopropanecarboxamide

HRID 1921286

反応式

HRID 1921286 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH:11]2[CH2:13][CH2:12]2)=[O:10])=[CH:4][C:3]=1[N+:14]([O-])=O.[H][H]>CO.[Pd]>[NH2:14][C:3]1[CH:4]=[C:5]([NH:8][C:9]([CH:11]2[CH2:13][CH2:12]2)=[O:10])[CH:6]=[CH:7][C:2]=1[CH3:1]

参加物

5

反応物 2

HCID 4104437N-(4-methyl-3-nitrophenyl)cyclopropanecarboxamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 24693537N-(3-amino-4-methylphenyl)cyclopropanecarboxamide収率 94.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

N-(4-Methyl-3-nitrophenyl)cyclopropanecarboxamide (409 mg) was hydrogenated over 10% Pd/C (50% wet, 80 mg) at atmospheric pressure of hydrogen in MeOH (20 mL) for 5 hr. The catalyst was removed by filtration through Celite® pad and the filtrate was evaporated in vacuo to give N-(3-amino-4-methylphenyl)cyclopropanecarboxamide (335 mg).

後処理

  1. customThe catalyst was removed by filtration through Celite® pad
  2. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-1148f2f8c34e49a9a37dc682729e6a91
出典データセット
uspto-grants-2012_05
特許番号
US08173684B2

関連ノート

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