Potassium Iodide → 3-ethyl-6-methyl-5-thiophen-2-yl-1H-pyridin-2-one

HRID 1921380ノート

反応式

HRID 1921380 の反応式
[CH2:1]([C:3]1[C:4]([O:15]C)=[N:5][C:6]([CH3:14])=[C:7]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=1)[CH3:2].[I-].[K+].C(#N)C.Cl[Si](C)(C)C>O>[CH2:1]([C:3]1[C:4](=[O:15])[NH:5][C:6]([CH3:14])=[C:7]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=1)[CH3:2]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 6342AcetonitrileHCID 6397ChlorotrimethylsilaneHCID 11673096HCID 11673096、化合物

生成物 1

HCID 674922683-ethyl-6-methyl-5-thiophen-2-yl-1H-pyridin-2-one収率 90%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To a solution of 3-ethyl-2-methoxy-6-methyl-5-(thiophen-2-yl)pyridine (6.15 g, 26.36 mmol) of the above reaction, potassium iodide (8.75 g, 52.71 mmol) and acetonitrile (80 mL) is added chlorotrimethylsilane (6.69 mL, 52.71 mmol) and the resulting cloudy mixture is heated to 80° C. for 2 hr. The reaction is cooled, poured into water and the solids collected by filtration, washed with water, with ethyl acetate and dried giving 3-ethyl-6-methyl-5-(thiophen-2-yl)-1H-pyridin-2-one as a yellow solid (90% yield).

後処理

  1. temperatureThe reaction is cooled
  2. filtrationthe solids collected by filtration
  3. washwashed with water, with ethyl acetate
  4. customdried

出典と根拠

ORDレコード
ord-42de59cfb65848209e4f91f7849f0b89
出典データセット
uspto-grants-2012_05
特許番号
US08173682B2

反応ノート

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