Ammonium formate → N-(5-aminopyridin-2-yl)-2-phenylacetamide

HRID 1921822

反応式

HRID 1921822 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:8][CH:9]=1)([O-])=O.C([O-])=O.[NH4+]>CCO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[N:8][CH:9]=1

参加物

6

反応物 2

HCID 2723923Ammonium formateHCID 4350143N-(5-nitropyridin-2-yl)-2-phenylacetamide

生成物 1

HCID 43144587N-(5-aminopyridin-2-yl)-2-phenylacetamide

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of N-(5-nitropyridin-2-yl)-2-phenylacetamide (4.35 g, 16.9 mmol) in EtOH (75 mL) and EtOAc (75 mL) is stirred at rt and ammonium formate (4.27 g) and 10% Pd/C (500 mg) are added. The mixture is heated at reflux for 30 min, cooled, filtered through celite and evaporated to afford the title compound as an off-white solid which was used without further purification.

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 30 min
  3. temperaturecooled
  4. filtrationfiltered through celite
  5. customevaporated

出典と根拠

ORDレコード
ord-9867299630f643cdaf4402d3a1d86ca3
出典データセット
uspto-grants-2012_05
特許番号
US08173656B2

関連ノート

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