Water → 1-Azabicyclo(2.2.2)octane-4-methanol
反応式
Cl.[N:2]12[CH2:9][CH2:8][C:5]([C:10](O)=[O:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[N:2]12[CH2:9][CH2:8][C:5]([CH2:10][OH:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2参加物
6
実験手順
Quinuclidine-4-carboxylic acid hydrochloride (6.0 g, 0.031 mmoles) in tetrahydrofuran (300 ml) was treated with lithium aluminum hydride (5.0 g, 0.137 mmoles) at ambient temperature for 18 hours. Water (20 ml) and 10% aqueous sodium hydroxide (7.5 ml) was added carefully and the mixture filtered, washing with diethyl ether. The combined filtrates were evaporated to dryness to give the title compound as a white solid 4.04 g, (91%): MS (+ve ion electrospray) m/z 142 (MH+, 100%)
後処理
- filtrationthe mixture filtered
- washwashing with diethyl ether
- customThe combined filtrates were evaporated to dryness
出典と根拠
- ORDレコード
- ord-2224e556c10c45a091a7488075604d68
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- USRE043390E1
反応ノート
読み込み中…