Diethyl Ether → Quinuclidin-4-ylmethanamine
反応式
[C:1]([C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[OH-].[Na+]>O1CCCC1.O>[NH2:2][CH2:1][C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2参加物
7
実験手順
4- Cyanoquinuclidine (0.31 g, 0.0028 moles) was reduced with lithium aluminium hydride (0.45 g, 0.012 moles) in tetrahydrofuran (20 ml) at ambient temperature for 18 hours. Diethyl ether (20 mls) was added followed by water (1.8 ml) and 10%w/v aqueous sodium hydroxide (0.68 ml) and the mixture stirred for 30 minutes. The mixture was then filtered and the filtrate concentrated in vacuo to give the title compound 0.3 g (94%).
後処理
- filtrationThe mixture was then filtered
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-bbaeeaf588c64c02960459fd74f88c51
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- USRE043390E1
反応ノート
読み込み中…