Chloroform → HCID 46235731、化合物

HRID 1925184ノート

反応式

HRID 1925184 の反応式
C(Cl)(Cl)Cl.[SH:5][C:6]1[C:7]([NH:16][C:17]([C:19]2([CH2:25][CH:26]([CH2:29][CH3:30])[CH2:27][CH3:28])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:18])=[CH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2.[C:31](Cl)(=[O:35])[CH:32]([CH3:34])[CH3:33]>N1C=CC=CC=1>[CH2:27]([CH:26]([CH2:29][CH3:30])[CH2:25][C:19]1([C:17]([NH:16][C:7]2[C:6]([S:5][C:31](=[O:35])[CH:32]([CH3:34])[CH3:33])=[CH:15][C:14]3[C:9]([CH:8]=2)=[CH:10][CH:11]=[CH:12][CH:13]=3)=[O:18])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)[CH3:28]

参加物

5

反応物 3

HCID 6212ChloroformHCID 62325Isobutyryl chlorideHCID 67427009HCID 67427009、化合物

生成物 1

HCID 46235731HCID 46235731、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a chloroform solution of the product obtained in step B) are added 1.05 mol equivalents of isobutyryl chloride and 2.5 mol equivalents of pyridine at room temperature. The mixture is stirred for 1 hour, concentrated and then n-hexane is added. The solids are filtered off and the filtrate is concentrated. The remaining residue is purified by silica gel column chromatography to obtain the desired title compound.

後処理

  1. concentrationconcentrated
  2. additionn-hexane is added
  3. filtrationThe solids are filtered off
  4. concentrationthe filtrate is concentrated
  5. customThe remaining residue is purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-3a4df17bdfa34ba6843680b713f5177e
出典データセット
uspto-grants-2012_05
特許番号
US08178583B2

反応ノート

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