Trifluoroacetic acid → HCID 67520244、化合物

HRID 1925370ノート

反応式

HRID 1925370 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=[CH:20]2.C(O)(C(F)(F)F)=O.[OH-].[Na+]>O.C(O)(C)C>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[NH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=[CH:20]2

参加物

7

反応物 4

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 24823732Methyl 6-aminonaphthalene-1-carboxylate

生成物 1

HCID 67520244HCID 67520244、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3776Isopropanol溶媒

反応条件

温度
90 °C

実験手順

The following reagents were combined in a flask and placed in a RT oil bath that was then heated to 90° C.: 4-Chloro-6,7-dimethoxyquinazoline (954 mg, 4.24 mmol), methyl 6-amino-1-naphthoate (857 mg, 4.24 mmol), TFA (098 mL, 12.7 mmol), and isopropanol (12 mL). The reaction was done before the bath reached the desired temperature. The mixture was diluted with water and made pH basic with 6N NaOH. The solid was filtered and rinsed with water and Et2O. The title compound was obtained as a pink solid.

後処理

  1. customThe following reagents were combined in a flask
  2. customplaced in a RT
  3. filtrationThe solid was filtered
  4. washrinsed with water and Et2O

出典と根拠

ORDレコード
ord-edb471c15f0748b295fbd310e88be657
出典データセット
uspto-grants-2012_05
特許番号
US08178557B2

反応ノート

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