Tetrahydrofuran → (4-Benzyloxy-phenyl)-acetic acid hydrazide

HRID 1927230ノート

反応式

HRID 1927230 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16](Cl)=[O:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1COCC1.C(N(CC)CC)C.O.[NH2:32][NH2:33]>O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([NH:32][NH2:33])=[O:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24654Hydrazine hydrate (1:1)HCID 113574424-Benzyloxyphenylacetyl Chloride

生成物 1

HCID 59287387(4-Benzyloxy-phenyl)-acetic acid hydrazide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 4-benzyloxyphenylacetyl chloride (1.1 g) and THF (10 mL) were added triethylamine (1.8 mL) and hydrazine hydrate (0.20 mL) at room temperature, which was stirred at the same temperature for 7.5 hours. Water was added to the reaction solution, which was then extracted with ethyl acetate, and the organic layer was washed with saturated brine. The solvent was evaporated under a reduced pressure, after which the residue was purified by silica gel chromatography (methanol:ethyl acetate=1:30) to obtain the titled compound (0.23 g).

後処理

  1. extractionwas then extracted with ethyl acetate
  2. washthe organic layer was washed with saturated brine
  3. customThe solvent was evaporated under a reduced pressure
  4. customafter which the residue was purified by silica gel chromatography (methanol:ethyl acetate=1:30)

出典と根拠

ORDレコード
ord-7b8bdd7125be462fb8d8e4b34ad552ff
出典データセット
uspto-grants-2012_05
特許番号
US08183264B2

反応ノート

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