Water → 4-Isopropoxy-1H-indole-2-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[C:11]([O:14][CH:15]([CH3:17])[CH3:16])[CH:10]=[CH:9][CH:8]=2)=[O:4].[Li+].[OH-].O>C1COCC1>[CH:15]([O:14][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]=[C:5]([C:3]([OH:4])=[O:2])[NH:6]2)([CH3:17])[CH3:16]参加物
5
実験手順
4-Isopropoxy-1H-indole-2-carboxylic acid methyl ester 76 (114 mg, 0.49 mmol) is dissolved in 5 ml of THF. A 2M-solution of LiOH in water (2.5 ml, 5 mmol) is added and the mixture is stirred for 48 hours. The solvent is then evaporated and the residue is partitioned between water and EtOAc. The water layer is acidified with HCl and extracted twice with EtOAc. The combined organic layers are washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated to give a yellow powder.
後処理
- customThe solvent is then evaporated
- customthe residue is partitioned between water and EtOAc
- extractionextracted twice with EtOAc
- washThe combined organic layers are washed with brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- customevaporated
- customto give a yellow powder
出典と根拠
- ORDレコード
- ord-f861786c00bd466f9cdd107182df21bd
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183366B2
反応ノート
読み込み中…