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Acetic Acid → N4-cyclohexyl-6-methyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

HRID 1930634
ノート
印刷プレビュー

反応式

HRID 1930634 の反応式
[CH:1]1([NH:7][C:8]2[C:9]3[CH2:30][NH:29][CH2:28][CH2:27][C:10]=3[N:11]=[C:12]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH:25]=[CH:24][N:23]=[C:22]4[CH3:26])=[CH:17][CH:16]=3)[N:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:31](O)(=O)C.C=O.C([BH3-])#N.[Na+]>CO>[CH:1]1([NH:7][C:8]2[C:9]3[CH2:30][N:29]([CH3:31])[CH2:28][CH2:27][C:10]=3[N:11]=[C:12]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH:25]=[CH:24][N:23]=[C:22]4[CH3:26])=[CH:17][CH:16]=3)[N:13]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 176Acetic AcidHCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 59333805N4-Cyclohexyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

生成物 1

HCID 46199431N4-cyclohexyl-6-methyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine収率 15.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

N4-Cyclohexyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (93 mg, 0.23 mmol) was dissolved in methanol (3 mL). Acetic acid (0.013 mL, 0.23 mmol) was added followed by formaldehyde (0.017 mL, 0.23 mmol) and sodium cyanoborohydride (14.48 mg, 0.23 mmol). The reaction mixture was stirred at room temperature for 1 h and the solvent was evaporated under reduced pressure. The crude material was dissolved in few drops of methanol, filtered and purified by preparative HPLC (acidic system) yielding N4-cyclohexyl-6-methyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (15.00 mg, 15.59%). MS (ES+) m/z 418.2 (M+H)+

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. dissolutionThe crude material was dissolved in few drops of methanol
  3. filtrationfiltered
  4. custompurified by preparative HPLC (acidic system)

出典と根拠

ORDレコード
ord-09d5c942db3846b18160e583f1aebf87
出典データセット
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08188101B2

反応ノート

読み込み中…

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