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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Acetic Acid → 6-methyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

HRID 1930660

印刷プレビュー

反応式

HRID 1930660 の反応式

[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[N:15]=[C:16]([NH:24][CH2:25][CH:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)[C:17]4[CH2:23][NH:22][CH2:21][CH2:20][C:18]=4[N:19]=3)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.[C:32](O)(=O)C.C=O.C([BH3-])#N.[Na+]>CO>[CH3:32][N:22]1[CH2:21][CH2:20][C:18]2[N:19]=[C:14]([NH:13][C:10]3[CH:11]=[CH:12][C:7]([N:3]4[CH:4]=[CH:5][N:6]=[C:2]4[CH3:1])=[CH:8][CH:9]=3)[N:15]=[C:16]([NH:24][CH2:25][CH:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)[C:17]=2[CH2:23]1

参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 176Acetic Acid

HCID 712Formaldehyde

HCID 5003444Sodium cyanoborohydride

HCID 59333815N2-(4-(2-Methyl-1H-imidazol-1-yl)phenyl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

生成物 1

HCID 461997396-methyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

収率 32.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

N2-(4-(2-Methyl-1H-imidazol-1-yl)phenyl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (49 mg, 0.12 mmol) was dissolved in methanol (3 mL). Acetic acid (6.69 μL, 0.12 mmol) was added followed by formaldehyde (8.70 μL, 0.12 mmol). The reaction mixture was stirred at room temperature for 15 minutes and sodium cyanoborohydride (7.34 mg, 0.12 mmol) was added. After 1 h the solvent was evaporated under reduced pressure, the crude purified twice by preparative HPLC (acidic system) yielding 6-methyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (16.40 mg, 32.4%). MS (ES+) m/z 434.3 (M+H)+

後処理

customAfter 1 h the solvent was evaporated under reduced pressure
customthe crude purified twice by preparative HPLC (acidic system)

出典と根拠

ORDレコード: ord-1a8800fc01994752bd994e8723604326
出典データセット: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08188101B2

反応ノート

読み込み中…

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