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Acetic Acid → N4-Ethyl-6-methyl-N2-(4-(oxazol-5-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

HRID 1930668
ノート
印刷プレビュー

反応式

HRID 1930668 の反応式
[CH2:1]([N:3]([CH2:26][CH:27]1[CH2:31][CH2:30][CH2:29][O:28]1)[C:4]1[C:5]2[CH2:25][NH:24][CH2:23][CH2:22][C:6]=2[N:7]=[C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:13][CH:12]=2)[N:9]=1)[CH3:2].[C:32](O)(=O)C.C=O.C([BH3-])#N.[Na+]>CO>[CH2:1]([N:3]([CH2:26][CH:27]1[CH2:31][CH2:30][CH2:29][O:28]1)[C:4]1[C:5]2[CH2:25][N:24]([CH3:32])[CH2:23][CH2:22][C:6]=2[N:7]=[C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:15][CH:16]=2)[N:9]=1)[CH3:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 176Acetic AcidHCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 59333759N4-Ethyl-N2-(4-(oxazol-5-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

生成物 1

HCID 46199742N4-Ethyl-6-methyl-N2-(4-(oxazol-5-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

N4-Ethyl-N2-(4-(oxazol-5-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (125 mg, 0.30 mmol, example 81a) was dissolved in methanol (3 mL). Acetic acid (0.017 mL, 0.30 mmol) was added followed by formaldehyde (0.022 mL, 0.30 mmol). The reaction was stirred at room temperature for 15 minutes and sodium cyanoborohydride (18.7 mg, 0.30 mmol) (MP—CNBH3) was added. The reaction was stirred overnight at room temperature. The MP—CNBH3 was filtered, the solvent evaporated under reduced pressure, the crude dissolved in methanol and purified by preparative HPLC N4-ethyl-6-methyl-N2-(4-(oxazol-5-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (29.8 mg, 21.04%) as acetate salt. MS (ES+) m/z 435.2 (M+H)+

後処理

  1. stirringThe reaction was stirred overnight at room temperature
  2. filtrationThe MP—CNBH3 was filtered
  3. customthe solvent evaporated under reduced pressure
  4. dissolutionthe crude dissolved in methanol
  5. custompurified by preparative HPLC N4-ethyl-6-methyl-N2-(4-(oxazol-5-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (29.8 mg, 21.04%) as acetate salt

出典と根拠

ORDレコード
ord-ec60bacc885f434e9023e78971b9cfbf
出典データセット
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08188101B2

反応ノート

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