1,1'-Carbonyldiimidazole → HCID 59333745、化合物

HRID 1930701

反応式

HRID 1930701 の反応式
N1([C:6]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[O:7])C=CN=C1.[O:13]1[CH2:17][CH2:16][CH2:15][CH:14]1[CH2:18][CH2:19]C(O)=O>ClCCl>[N:8]1([C:6](=[O:7])[CH2:19][CH2:18][CH:14]2[CH2:15][CH2:16][CH2:17][O:13]2)[CH:12]=[CH:11][N:10]=[CH:9]1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 2631613-(Oxolan-2-yl)propanoic acid

生成物 1

HCID 59333745HCID 59333745、化合物収率 100.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Di-(1H-imidazol-1-yl)methanone (0.554 g, 3.42 mmol) was added in small portions to a stirred solution of 3-(tetrahydrofuran-2-yl)propanoic acid (0.469 g, 3.25 mmol) in dichloromethane (3 mL) at room temperature under argon. The reaction mixture is stirred at room temperature for 2 hours. The mixture was washed twice with water, dried over MgSO4 and concentrated resulting a quantitative yield of 1-(1H-imidazol-1-yl)-3-(tetrahydrofuran-2-yl)propan-1-one (632 mg, 100%).

後処理

  1. washThe mixture was washed twice with water
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-2cb04fbc9ad746529d70a437f4cdea17
出典データセット
uspto-grants-2012_05
特許番号
US08188101B2

関連ノート

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