Iodoethane → Methyl 3-ethoxy-4-methoxybenzoate
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6].C(=O)([O-])[O-].[K+].[K+].[CH2:20](I)[CH3:21]>CN(C)C=O>[CH2:20]([O:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6])[CH3:21]参加物
5
実験手順
To a mixture of methyl 3-hydroxy-4-methoxybenzoate (4.00 g) and potassium carbonate (4.55 g) in dimethylformamide (20 mL) was added ethyl iodide (2.63 mL) under water-cooling and the mixture was stirred for 2 hours at ambient temperature. The mixture was partitioned between water and ethyl acetate. The separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo to give methyl 3-ethoxy-4-methoxybenzoate as pale brown powders (4.55 g).
後処理
- temperaturecooling
- customThe mixture was partitioned between water and ethyl acetate
- washThe separated organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-74d2c9a455b34eb781fbbe8965161b48
- 出典データセット
- uspto-grants-2002_05
- 特許番号
- US06384080B1
反応ノート
読み込み中…