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Ethyl bromoacetate → 2-{3-[3-(1-Triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-yl}-acetic acid ethyl ester

HRID 1934813
ノート
印刷プレビュー

反応式

HRID 1934813 の反応式
[C:1]1([C:7]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][N:16]3[C:20](=[O:21])[C:19]([CH3:32])([C:22]4[C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH:25]=[CH:24][CH:23]=4)[NH:18][C:17]3=[O:33])[N:10]=[CH:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49].[H-].[Na+]>CN(C)C=O>[CH2:51]([O:50][C:48](=[O:49])[CH2:47][N:18]1[C:19]([CH3:32])([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=2)[C:20](=[O:21])[N:16]([CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][N:8]([C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH:12]=2)[C:17]1=[O:33])[CH3:52]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 224668503-[3-(1-Triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-imidazolidin-2,4-dione

生成物 1

HCID 572281992-{3-[3-(1-Triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-yl}-acetic acid ethyl ester収率 99%

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

実験手順

0.082 g(0.14 mmol) of 3-[3-(1-triphenylmethyl-imidazol-4-yl)-propyl]-5-methyl-5-naphthalen-1-yl-imidazolidin-2,4-dione prepared in Example 1-1) and 0.023 ml(0.21 mmol) of ethyl bromoacetate were dissolved in 5 ml of dimethylformamide. 0.017 g(0.21 mmol) of sodium hydride [NaH] was added thereto and the resulting solution was stirred for one hour. Dimethylformamide was removed under reduced pressure and the residue was dissolved in ethyl acetate and then washed with saturated sodium chloride solution. Removal of ethyl acetate under reduced pressure provided 0.092 g(Yield: 99%) of title compound.

後処理

  1. customDimethylformamide was removed under reduced pressure
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with saturated sodium chloride solution
  4. customRemoval of ethyl acetate under reduced pressure

出典と根拠

ORDレコード
ord-2bd0fcd875e24c319a7a18386932374c
出典データセット
uspto-grants-2002_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06384061B1

反応ノート

読み込み中…

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