Thionyl Chloride → 3-(4-Methoxyphenyl)-2-phenylpropionyl chloride

HRID 1935735

反応式

HRID 1935735 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1.S(Cl)([Cl:22])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([Cl:22])=[O:12])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 977393-(4-Methoxyphenyl)-2-phenylpropionic acid

生成物 1

HCID 111403233-(4-Methoxyphenyl)-2-phenylpropionyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-(4-Methoxyphenyl)-2-phenylpropanoic acid (12.5 g, 0.049 mol) was converted to its acid chloride by treatment with thionyl chloride (8.2 ml) in dry dichloromethane (75 ml) at 40° C. Excess thionyl chloride and dichloromethane were evaporated off. The crude product was used in the next step without purification.

後処理

  1. customExcess thionyl chloride and dichloromethane were evaporated off
  2. customThe crude product was used in the next step without purification

出典と根拠

ORDレコード
ord-8330fac80b4f466ab997698fb37b3886
出典データセット
uspto-grants-2002_05
特許番号
US06388090B2

関連ノート

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