Tetrahydrofuran → 3,5-Dihydroxy-1-adamantyl methacrylate

HRID 1936524

反応式

HRID 1936524 の反応式
[C:1]12([OH:13])[CH2:10][C:5]3([OH:11])[CH2:6][CH:7]([CH2:9][C:3]([OH:12])([CH2:4]3)[CH2:2]1)[CH2:8]2.C(N(CC)CC)C.O1CCCC1.[C:26](Cl)(=[O:30])[C:27]([CH3:29])=[CH2:28]>O>[C:26]([O:13][C:1]12[CH2:10][C:5]3([OH:11])[CH2:6][CH:7]([CH2:9][C:3]([OH:12])([CH2:4]3)[CH2:2]1)[CH2:8]2)(=[O:30])[C:27]([CH3:29])=[CH2:28]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 98990221,3,5-Adamantanetriol

生成物 1

HCID 130073943,5-Dihydroxy-1-adamantyl methacrylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

10 mmol of 1,3,5-adamantanetriol, 10 mmol of triethylamine, and 40 ml of tetrahydrofuran were mixed, and 10 mmol of methacrylic acid chloride was added dropwise to the mixture for about 30 minutes. After completion of the dropwise addition, the mixture was stirred at room temperature for 24 hours. After the reaction had been completed, to the reaction mixture was added water, followed by purification by column chromatography to give 1-methacryloyloxy-3,5-dihydroxyadamantane.

後処理

  1. additionAfter completion of the dropwise addition
  2. customfollowed by purification by column chromatography

出典と根拠

ORDレコード
ord-117c406f89914498bb4879bfd9ee1c9f
出典データセット
uspto-grants-2002_05
特許番号
US06391520B1

関連ノート

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