Hydrochloric Acid → 5-Ethyl-2-pyridyl-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetic acid

HRID 1938510ノート

反応式

HRID 1938510 の反応式
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:19][C:20]([O:22]CC)=[O:21])[C:11](=[O:18])[C:12]([CH:15]([CH3:17])[CH3:16])([CH3:14])[N:13]=2)=[N:7][CH:8]=1)[CH3:2].[OH-].[Na+].Cl>O1CCCC1>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:19][C:20]([OH:22])=[O:21])[C:11](=[O:18])[C:12]([CH:15]([CH3:17])[CH3:16])([CH3:14])[N:13]=2)=[N:7][CH:8]=1)[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22450190Ethyl 2-(5-ethyl-2-pyridyl)-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate

生成物 1

HCID 224501785-Ethyl-2-pyridyl-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A stirred solution of ethyl 2-(5-ethyl-2-pyridyl)-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate (2.12 g, 6.41 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (8 mL). The resulting mixture is stirred at room temperature for 16 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is acidified with concentrated hydrochloric acid and then extracted with ether. The organic extract is dried over magnesium sulfate, vacuum filtered through diatomaceous earth and concentrated in vacuo to give the title product as a white solid, mp 134°-136° C.

後処理

  1. waitAfter this period
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customto obtain a residue
  4. extractionextracted with ether
  5. extractionThe organic extract
  6. dry with materialis dried over magnesium sulfate, vacuum
  7. filtrationfiltered through diatomaceous earth
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-071023308b4146eeb58bed47fce085d5
出典データセット
uspto-grants-1997_12
特許番号
US05693658

反応ノート

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