Hydrochloric Acid → 5-Bromothiophene-2-carboxylic acid

HRID 1940022ノート

反応式

HRID 1940022 の反応式
S([O-])([O-])=O.[Na+].[Na+].[Br:7][C:8]1[S:12][C:11]([C:13]([OH:15])=[O:14])=[CH:10][C:9]=1S(Cl)(=O)=O.[OH-].[Na+].Cl>O>[Br:7][C:8]1[S:12][C:11]([C:13]([OH:15])=[O:14])=[CH:10][CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24437Sodium SulfiteHCID 214656365-Bromo-4-(chlorosulfonyl)thiophene-2-carboxylic acid

生成物 1

HCID 3491155-Bromothiophene-2-carboxylic acid収率 172.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

27.5 g of sodium sulfite are dissolved in 300 ml of water, and a total of 35 g of 5-bromo-4-chlorosulfonylthiophene-2-carboxylic acid is added, in portions, at 70° C., with a pH of 9-11 being maintained using 10N NaOH. The mixture is subsequently stirred at 70° C. for 2 h and then adjusted to pH=1 with HCl, after which the product is filtered off with suction. 41 g of colorless crystals are obtained.

後処理

  1. temperaturebeing maintained
  2. filtrationafter which the product is filtered off with suction

出典と根拠

ORDレコード
ord-eeec85c405a441ab85f09245455a2561
出典データセット
uspto-grants-1997_12
特許番号
US05698581

反応ノート

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